QANDLI VA QANDSIZ DIABETLARDA MEDAOSTI BEZINING MORFOFUNKSIONAL HOLATI VA SOLISHTIRMA ANATOMIYASI
Keywords:
qandli diabet, qandsiz diabet, medaosti bezi, pankreas morfologiyasi, morfofunksional holat, Langerhans orolchalari, β-hujayralar, insulin sekretsiyasi, ekzokrin faoliyat, fibroz, vaskulyar o‘zgarishlar, hujayraviy degeneratsiya, endokrin regulyatsiya, metabolik buzilishlar, solishtirma anatomiya.Abstract
Ushbu maqolada qandli diabet (1- va 2-tur) hamda qandsiz diabet sharoitida medaosti bezining (pankreasning) morfofunksional holati, uning to‘qima tuzilishi, endokrin va ekzokrin faoliyatidagi o‘zgarishlar tahlil qilingan. Pankreasda insulin ishlab chiqaruvchi β-hujayralarning degeneratsiyasi, Langerhans orolchalari soni va hajmining kamayishi, shuningdek, qandsiz diabetga xos bo‘lgan neyroendokrin regulyatsiya buzilishlari o‘rganilgan. Morfologik tahlillar pankreatik to‘qimada fibroz, vaskulyar o‘zgarishlar, hujayraviy distrofiyalar va sekretor disfunksiyalar mavjudligini ko‘rsatdi. Diabetning turli shakllari pankreasning struktura va funksiyasiga turlicha ta’sir qilishi aniqlanib, ushbu o‘zgarishlarning klinik ko‘rinishlar va metabolik jarayonlar bilan o‘zaro bog‘liqligi ilmiy asosda ochib berilgan. Tadqiqot natijalari diabet kasalliklarini erta aniqlash, differensial diagnostika va samarali davolash strategiyalarini takomillashtirish uchun muhim ilmiy-amaliy ahamiyatga ega.
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