PATHOPHYSIOLOGICAL AND CLINICAL-STATISTICAL ANALYSIS OF PROTEIN METABOLISM DISINTEGRATION
Keywords:
To provide a quantitative and qualitative analysis of the imbalance between protein anabolism and catabolism, and to systematize the clinical indicators of nitrogen balance deficiency.Abstract
According to modern hospital statistics, 25–40% of patients hospitalized with somatic diseases exhibit varying degrees of protein-energy malnutrition (PEM). In intensive care units (ICU), this figure rises to 60–80%, reducing treatment efficacy by 1.5–2 times and increasing the risk of hospital mortality by 30%. Protein metabolism dysfunction is not merely a consequence of organ failure but is an independent prognostic factor determining the aggressive course of the pathological process.