O‘TKIR PANKREATIT KELIB CHIQISHI VA DAVOLASHNING BIOKIMYOVIY ASOSLARI
Keywords:
o‘tkir pankreatit, tripsinogen, fosfolipaza A2, oksidativ stress, sitokinlar, pankreatik nekroz, ferment inhibitorlari, lipaza, amilaza, NF-κB.Abstract
O‘tkir pankreatitning molekulyar va biokimyoviy patogenezi zamonaviy tahlillar asosida yoritilgan. Patologiyaning trigger mexanizmi sifatida asinar hujayralar ichida tripsinogenning muddatidan avval autokatalitik aktivatsiyasi va uning proteolitik kaskadni ishga tushirishdagi roli tahlil qilinadi. Tadqiqotda oksidativ stressning mitoxondrial disfunksiyaga ta’siri, tizimli yallig‘lanish javobi sindromini (SIRS) yuzaga keltiruvchi “sitokin bo‘roni” mediatorlari hamda hujayralarning nekroz va apoptoz nisbatini belgilovchi biokimyoviy omillar atroflicha ko‘rib chiqilgan. Shuningdek, fermentativ ingibitsiya, antioksidant himoya tizimini faollashtirish va gomeostazni tiklovchi infuzion terapiyaning biokimyoviy effektivligi ilmiy asoslab berilgan. Maqola klinik biokimyo va gastroenterologiya sohasidagi so‘nggi yutuqlarga tayanib, kasallikni patogenetik davolash strategiyalarini optimallashtirishga xizmat qiladi.
References
1. S.Sh.Saidobbozov,S.S.Amanbayeva, J.D.Kuvatov/BIOKIMYO//“Omadbek print number one” MCHJ. Andijon:2025.-429 b.
2. Lankisch P.G., Apte M., Banks P.A. Acute pancreatitis // The Lancet. - 2015. - Vol. 386, № 9988. - P. 85–96.
3. Petrov M.S., Yadav D. Global epidemiology and holistic prevention of pancreatitis // Nature Reviews Gastroenterology & Hepatology. - 2019. - Vol. 16, № 3. -P. 175–184.
4. Saluja A.K., Bhagat L., Lee H.S. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini // American Journal of Physiology.-1999. - Vol. 276, № 4. - P. G835–G842.
5. Pandol S.J., Saluja A.K., Imrie C.W., Banks P.A. Acute pancreatitis: bench to the bedside // Gastroenterology. - 2007. - Vol. 132, № 3. - P. 1127–1151.
6. Mukherjee R., Bhatt D.L., Bhatt D.L. Role of oxidative stress in pancreatitis // Journal of Gastroenterology and Hepatology. - 2014. - Vol. 29, Suppl. 4. - P. 55–60.
7. Makhija R., Kingsnorth A.N. Cytokine storm in acute pancreatitis // Journal of the Hepato-Biliary-Pancreatic Sciences. - 2002. - Vol. 9, № 4. - P. 401- 410.
8. Gukovskaya A.S., Pandol S.J. Cell death pathways in pancreatitis and pancreatic cancer // Pancreatology. - 2004. - Vol. 4, № 6. - P. 567-586.
9. Tenner S., Baillie J., DeWitt J., Vege S.S. American College of Gastroenterology guideline: management of acute pancreatitis // American Journal of Gastroenterology. - 2013. - Vol. 108, № 9. - P. 1400-1415.
10.Urunov A.J., Yusupov Sh.A. Oshqozon osti bezi kasalliklari: diagnostika va davolash asoslari. - Toshkent: Tibbiyot, 2018. - 214 b.
11.Toouli J., Brooke-Smith M., Bassi C. et al. Guidelines for the management of acute pancreatitis // Journal of Gastroenterology and Hepatology. - 2002. - Vol. 17, Suppl. - P. S15–S39.
