DORI VOSITALARINING ORGANIZMDAGI BIOTRANSFORMATSIYASI VA METABOLIZMINING KIMYOVIY ASOSLARI.
Keywords:
biotransformatsiya, metabolizm, sitoxrom P450, kon'yugatsiya, oksidlanish, gidroliz, farmakokinetika, dori-dorarol o'zaro ta'sir, ferment induksiyasi.Abstract
Ushbu maqolada dori vositalarining organizmga kirganidan keyin bajariladigan kimyoviy o'zgarishlar, biotransformatsiyaning I va II fazalari, shuningdek, ushbu jarayonlarga ta'sir etuvchi omillar tahlil qilingan.
References
1. Gonzalez F.J., Tukey R.H. Drug Metabolism. In: Brunton L.L., Lazo J.S., Parker K.L., editors. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York: McGraw-Hill, 2006. P. 71-95.
2. Zanger U.M., Schwab M. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & Therapeutics, 2013, 138(1): 103-141.
3. Ingelman-Sundberg M. Pharmacogenetics of cytochrome P450 and its applications in drug therapy. Trends in Pharmacological Sciences, 2004, 25(4): 193-200.
4. Rowland A., Miners J.O., Mackenzie P.I. The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification. International Journal of Biochemistry & Cell Biology, 2013, 45(6): 1121-1132.
5. Gamage N.U., Tsvetanov S., Duggleby R.G., et al. Structure and function of human sulfotransferases. Drug Metabolism Reviews, 2006, 38(4): 663-678.
6. Evans D.A.P., Mahgoub A., Sloan T.P., et al. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. Journal of Medical Genetics, 1980, 17(2): 102-105.
7. Kuehl P., Zhang J., Lin Y., et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nature Genetics, 2001, 27(4): 383-391.
8. Lin J.H., Lu A.Y.H. Inhibition and induction of cytochrome P450 and the clinical implications. Clinical Pharmacokinetics, 1998, 35(5): 361-390.
9. Meyer U.A. Pharmacogenetics and adverse drug reactions. The Lancet, 2000, 356(9242): 1667-1671.
10. Rendic S., Di Carlo F.J. Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metabolism Reviews, 1997, 29(1-2): 413-580.
11. Wilkinson G.R. Drug metabolism and variability among patients in drug response. The New England Journal of Medicine, 2005, 352(21): 2211-2221.
12. Nebert D.W., Russell D.W. Clinical importance of the cytochromes P450. The Lancet, 2002, 360(9340): 1155-1162.
