JIGAR SIRROZIDA QIZILO‘NGACHDAN QON KETISHINING PROFILAKTIKASINI TAKOMILLASHTIRISH
Keywords:
jigar sirrozi, qizilo‘ngach varikoz kengaygan venalari, qon ketish profilaktikasi, endoskopik ligatsiya, beta-blokerlar, portal gipertenziya.Abstract
Jigar sirrozi bilan og‘rigan bemorlarda qizilo‘ngach varikoz kengaygan venalaridan (QVK) qon ketishining birlamchi va ikkilamchi profilaktikasini takomillashtirish bo‘yicha yangi yondashuvlarni baholash. Materiallar va usullar: 2019-2023 yillar davomida 186 nafar jigar sirrozi (Child-Pugh A/B/C: 41/88/57) tashxisi qo‘yilgan bemor tadqiqotga kiritildi. Bemorlar uch guruhga bo‘lindi: I guruh (n=62) - an’anaviy beta-bloker (propranolol) monoterapiyasi; II guruh (n=64) - endoskopik varikoz vena ligatsiyasi (EVVL); III guruh (n=60) - kombinatsiyalashgan terapiya (propranolol + EVVL). Kuzatuv muddati 24 oy. Natijalar: 24 oylik kuzatuvda qon ketish chastotasi: I guruhda 32,2%, II guruhda 18,7%, III guruhda 8,3% (p<0,05). O‘lim ko‘rsatkichi III guruhda sezilarli darajada past bo‘ldi (6,7% vs I guruhda 14,5%). Xulosa: Kombinatsiyalashgan profilaktik strategiya (EVVL + kardioselektiv beta-bloker) jigar sirrozi bilan og‘rigan bemorlarda qon ketish xavfini 74% ga kamaytiradi va hayot sifatini yaxshilaydi.
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